Уважаемый Чат!
Критерием латентного дефицита при нормальном СОЭ (нормальных острофаз. показателях) является уровень ферритина и только! Он отражает запасы железа в организме. Дефицитный эритропоэз определяется стойким снижением % насыщения трансферрина железом (СЗ/ОЖСС) вследствие того, что СЖ крайне вариабельно в течение суток и зависит от рациона. Тогда же можно "увидеть" микрофракцию эритроцитов по увеличению RDW.
Если Вам интересно, каковы критерии латентности и как часто при этом снижается железо, повышается ОЖСС, то пожалуйста тезисы статьи (выделено мной):
Eur J Clin Chem Clin Biochem. 1994 Jan;32(1):19-25.
Efficacy of transferrin determination in human sera in the diagnosis of iron deficiency.
Withold W, Neumayer C, Beyrau R, Heins M, Schauseil S, Rick W.
Institut fur Klinische Chemie und Laboratoriumsdiagnostik, Heinrich-Heine-Universitat Dusseldorf, Germany.
Apparently healthy persons (n = 425) as well as 264 patients characterized by an iron concentration in serum < 7.2 mumol/l were examined. A latent iron deficiency was defined as a concentration of ferritin < 20 micrograms/l (males) and < 15 micrograms/l (females), without anaemia; manifest iron deficiency defined by an additional presence of hypochromic microcytic anaemia. Fifty-nine of 425 (= 14%) apparently healthy persons showed a latent iron deficiency. In the remaining 366 we established the following reference intervals for the concentration of transferrin in serum [mumol/l]: 25.2-45.3 (males), 29.1-54.5 (females, < or = 25 years of age) and 25.3-48.6 (females, > 25 years of age). Eight of 59 (= 14%) apparently healthy persons with latent iron deficiency had a transferrin concentration above the reference interval. Sixty-one of 264 (= 23%) patients with an iron concentration < 7.2 mumol/l showed a ferritin concentration < 20 micrograms/l (males) and < 15 micrograms/l (females). Thirty-eight of these 61 patients (= 62%) had a manifest iron deficiency. In 18 of these 38 patients (= 47%) the transferrin concentration was increased. For our 264 patients we determined the diagnostic validity of an increased transferrin concentration for diagnosis of iron deficiency, assuming an iron deficiency if the concentration of ferritin remained below the discrimination values mentioned above: The diagnostic sensitivity was 36%, the diagnostic specificity 97%, the predictive value of the positive test result 79% and the predictive value of the negative test result 83%.
По железодефициту и нарушениям терморегуляции - только ссылки на 2 обзора (регулярных статей еще больше):
Crit Rev Food Sci Nutr. 1996 Dec;36(8):747-63.
Iron and thermoregulation: a review.
Brigham D, Beard J.
Rosenzweig PH, Volpe SL.
Iron, thermoregulation, and metabolic rate.
Crit Rev Food Sci Nutr. 1999 Mar;39(2):131-48.
Микроцитарные гипохромные анемии кроме ЖД могут (потенциально) быть гемолитич., талассемии и анемии хр. заболеваний, еще реже сюда попадают сидеробластные.
Как видите 2 строчки - не такое уж и большое описание даже для интернета.
Можете проверить - за рубежом тоже самое пишут, напр.
Vnitr Lek. 2001 Mar;47(3):166-74.
[Microcytic and hypochromic anemias]
Chrobak L.
Oddeleni klinicke hematologie Fakultni nemocnice, Hradec Kralove.
In the majority of cases, microcytosis is the result of impaired hemoglobin synthesis. Disorders of iron metabolism and protoporphyrin and heme synthesis, as well as impaired globin synthesis, lead to defective hemoglobin production and to the generation of microcytosis and microcytic anemia. Iron deficiency anemie, anemia of chronic diseases, thalassemias, congenital sideroblastic anemias and homozygous HbE disease are the main representatives of microcytosis and microcytic anemias. Serum iron, total iron binding capacity, transferrin saturation, serum ferritin, serum transferrin receptor, transferrin receptor-ferritin index, and zinc-protoporhyrin concentration in erythrocytes are tests used for assessment of iron deficiency. The convention laboratory test for diagnosing iron deficiency is the measurement of serum ferritin. The most precise method for evaluating body iron stores is the examination for iron on aspirated bone marrow or marrow biopsy. Increased content of Hb A2 over 3.5% is diagnostic for beta-thalassemia. Presence of ringed sideroblasts is characteristic of sideroblastic anemias. Hemoglobin electrophoresis is required for the diagnosis of hemoglobinopathy E.
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