Еще один кейс, показывающий, что сердечные проблемы, вызванные перегрузкой организма железом, потенциально обратимы при выведении железа из организма/его хелировании:
Haemophilia. 2010 Mar 4.
Remission of paroxysmal atrial fibrillation with iron reduction in haemophilia A.
Zacharski LR, McKernan L, Metzger ME, Malone MG, Samnotra V, Bhargava A, Steiner PR, Rauwerdink CA, Ornstein DL, Cornell CJ.
Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Summary. Two male first cousins with mild haemophilia A had baseline factor VIII levels of 12-15% and experienced bleeding requiring coagulation factor infusion therapy with trauma and surgical procedures. Both the patients with haemophilia A also had electrocardiographically documented symptomatic paroxysmal atrial fibrillation (PAF) for several years that had become resistant to pharmacological suppression. Radiofrequency ablation was considered in both the cases but deferred considering refusal of consent by the patients to undergo the procedure. Remission of arrhythmias has been reported in patients with iron-overload syndromes. Body iron stores assessed by serum ferritin levels were elevated in both men but neither had the C282Y or H63D genes for haemochromatosis. Calibrated reduction of iron stores by serial phlebotomy, avoiding iron deficiency, was followed by remission of symptomatic PAF in both cases. Iron reduction may be an effective treatment for arrhythmias apart from the classic iron-overload syndromes and deserves further study particularly in patients with bleeding disorders who might be at risk for arrhythmias and other diseases of ageing.
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Более ранние публикации в полной версии:
Blood. 2007 Jan 1;109(1):362-4.
Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis. [Ссылки доступны только зарегистрированным пользователям ]
Br Heart J. 1995 Jan;73(1):73-5.
Haemochromatosis presenting as congestive cardiac failure. [Ссылки доступны только зарегистрированным пользователям ]
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