Atrial Fibrillation Management Strategies and Early Mortality After Myocardial Infarction: Results From the Valsartan in Acute Myocardial Infarction (VALIANT) Trial
Nilsson KR Jr, Al-Khatib SM, Zhou Y, et al.
Heart 2010;96:838-842.
Study Question: Does a rhythm-control strategy for atrial fibrillation (AF) affect outcomes compared to a rate-control strategy early after myocardial infarction (MI)?
Continuing Warfarin Therapy Is Superior to Interrupting Warfarin With or Without Bridging Anticoagulation Therapy in Patients Undergoing Pacemaker and Defibrillator Implantation
Ahmed I, Gertner E, Nelson WB, et al.
Heart Rhythm 2010;7:745-749.
Study Question: Is therapy with warfarin safer than heparin in patients undergoing device implantation?
Warfarin Genotyping Reduces Hospitalization Rates: Results From the MM-WES (Medco-Mayo Warfarin Effectiveness Study)
Epstein RS, Moyer TP, Aubert RE, et al.
J Am Coll Cardiol 2010;55:2804-2812.
Study Question: Does genotype testing for functional variants of CYP2C9 and VKORC1 in patients initiating warfarin therapy lead to reduced hospitalizations?
Outcomes in Patients With De Novo Left Main Disease Treated With Either Percutaneous Coronary Intervention Using Paclitaxel-Eluting Stents or Coronary Artery Bypass Graft Treatment in the Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) Trial
Morice MC, Serruys PW, Kappetein AP, et al.
Circulation 2010;121:2645-2653.
Study Question: What are the outcomes in the prespecified subgroup of patients with left main (LM) disease in the SYNTAX trial?
Geographic Variation in Medicare Drug Spending
Zhang Y, Baicker K, Newhouse JP.
N Engl J Med 2010;Jun 9:[Epub ahead of print].
Study Question: Do Medicare patients who spend more on pharmaceuticals to control chronic conditions have fewer physician visits?
Genetic Determinants of Treatment Benefit of the Angiotensin-Converting Enzyme-Inhibitor Perindopril in Patients With Stable Coronary Artery Disease
Brugts JJ, Isaacs A, Boersma E, et al.
Eur Heart J 2010;Jun 10:[Epub ahead of print].
Study Question: Do sequence variations involving genes in angiotensin-converting enzyme (ACE)-related pathways affect clinical response to ACE therapy in patients with stable coronary artery disease (CAD)?
Cardiac Performance Measure Compliance in Outpatients: The American College of Cardiology and National Cardiovascular Data Registry’s PINNACLE (Practice Innovation And Clinical Excellence) Program
Chan PS, Oetgen WJ, Buchanan D, et al.
J Am Coll Cardiol 2010;56:8-14.
Study Question: What are the results of the first large office-based quality improvement study of outpatients with coronary artery disease (CAD), heart failure, and atrial fibrillation?
Mid-Region Pro-Hormone Markers for Diagnosis and Prognosis in Acute Dyspnea: Results From the BACH (Biomarkers in Acute Heart Failure) Trial
Maisel A, Mueller C, Nowak R, et al.
J Am Coll Cardiol 2010;55:2062-2076.
Study Question: What is the diagnostic utility of mid-regional pro–atrial natriuretic peptide (MR-proANP) for the diagnosis of acute heart failure (AHF) and the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with AHF?
Patients With Acute Coronary Syndromes and Elevated Levels of Natriuretic Peptides: The Results of the AVANT GARDE-TIMI 43 Trial
Scirica BM, Morrow DM, Bode C, et al.
Eur Heart J 2010;June 17:[Epub ahead of print].
Study Question: What is the effect of early inhibition of the renin–angiotensin–aldosterone system (RAAS) in acute coronary syndrome (ACS) patients with preserved left ventricular function on hemodynamic stress?
Randomized Trial of Paclitaxel- Versus Sirolimus-Eluting Stents for Treatment of Coronary Restenosis in Sirolimus-Eluting Stents: The ISAR-DESIRE 2 (Intracoronary Stenting and Angiographic Results: Drug Eluting Stents for In-Stent Restenosis 2) Study
Mehilli J, Byrne RA, Tiroch K, et al., on behalf of the ISAR-DESIRE 2 Investigators.
J Am Coll Cardiol 2010;55:2710-2716.
Study Question: What is the comparative efficacy of repeat sirolimus-eluting stent (SES) versus implantation with paclitaxel-eluting stent (PES) for patients with SES restenosis requiring reintervention?
Aspirin for the Primary Prevention of Cardiovascular Events in People With Diabetes
Pignone M, Alberts MJ, Colwell JA, et al., on behalf of the American Diabetes Association, American Heart Association, and American College of Cardiology.
J Am Coll Cardiol 2010;55:2878-2886.
Perspective: The following are 10 points to remember about this expert consensus document.
Prognostic Implications of the Urinary Albumin to Creatinine Ratio in Veterans of Different Ages With Diabetes
O’Hare AM, Hailpern SM, Pavkov ME, et al.
Arch Intern Med 2010;170:930-936.
Study Question: Albuminuria is associated with an increased risk of death independent of level of renal function. Is this association similar for adult diabetics of all ages?