“SOURCE” of Enthusiasm for Transcatheter Aortic Valve Implantation
Tuzcu EM, Kapadia SR, Svensson LG, et al.
Circulation 2010;122:8-10.
Perspective: Transcatheter aortic valve implantation (TAVI) is one of the most exciting recent advances in interventional cardiology and has been a well coordinated collaborative effort by both physicians and surgeons.
Repair of the Bicuspid Aortic Valve: A Viable Alternative to Replacement With a Bioprosthesis
Ashikhmina E, Sundt TM III, Dearani JA, Connolly HM, Li Z, Schaff HV.
J Thorac Cardiovasc Surg 2010;139:1395-1401.
Study Question: What is the relative safety and durability of bicuspid aortic valve repair compared to bioprosthetic aortic valve replacement?
Center Variation and Outcomes Associated With Delayed Sternal Closure After Stage 1 Palliation for Hypoplastic Left Heart Syndrome
Johnson JN, Jaggers J, Li S, et al.
J Thorac Cardiovasc Surg 2010;139:1205-1210.
Study Question: What are the differences in outcomes between a primary or delayed chest closure strategy in infants undergoing stage 1 palliation for hypoplastic left heart syndrome (HLHS)?
Total Anomalous Pulmonary Venous Connection: Results of Surgical Repair of 100 Patients at a Single Institution
Kelle AM, Backer CL, Gossett JG, Kaushal S, Mavroudis C.
J Thorac Cardiovasc Surg 2010;139:1387-1394.
Study Question: What are the outcomes of patients undergoing surgical repair of total anomalous pulmonary venous connection (TAPVC)?
Screening Asymptomatic Subjects for Subclinical Atherosclerosis: Can We, Does It Matter, and Should We?
Shah PK.
J Am Coll Cardiol 2010;56:98-105.
Conclusions: The following are 10 points to remember about this viewpoint and commentary.
Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes
Bergenstal RM, Tamborlane WV, Ahmann A, et al.
N Engl J Med 2010;Jun 29:[Epub ahead of print].
Study Question: What is the relative value of a sensor-augmented pump therapy (pump therapy), as compared to a regimen of multiple daily insulin injections (injection therapy) in patients with type 1 diabetes?
Prandial Inhaled Insulin Plus Basal Insulin Glargine Versus Twice Daily Biaspart Insulin for Type 2 Diabetes: A Multicentre Randomised Trial
Rosenstock J, Lorber DL, Gnudi L, et al.
Lancet 2010;375:2244-2253.
Study Question: Insulin therapy is often a delayed strategy in patients with type 2 diabetes mellitus because it is associated with weight gain, hypoglycemia, and the need for subcutaneous injections. What is the efficacy and safety of prandial Technosphere inhaled insulin compared with twice daily biaspart insulin?
Acquired von Willebrand Syndrome After Continuous-Flow Mechanical Device Support Contributes to a High Prevalence of Bleeding During Long-Term Support and at the Time of Transplantation
Uriel N, Pak SW, Jorde UP, et al.
J Am Coll Cardiol 2010;Jun 30:[Epub ahead of print].
Study Question: What is the prevalence and mechanism of bleeding events in patients receiving left ventricular assist device (LVAD) support?
Long-Term Outcome of a Routine Versus Selective Invasive Strategy in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Meta-Analysis of Individual Patient Data
Fox KA, Clayton TC, Damman P, et al., on behalf of the FIR Collaboration.
J Am Coll Cardiol 2010;55:2435-2445.
Study Question: What is the effect of routine invasive (RI) strategy on the long-term frequency of cardiovascular (CV) death or nonfatal myocardial infarction (MI)?
Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-Analysis of 11 Randomized Controlled Trials Involving 65,229 Participants
Ray KK, Kondapally Seshasai SR, Erqou S, et al.
Arch Intern Med 2010;170:1024-1031.
Study Question: Does statin use for primary prevention reduce risk of all-cause mortality?
Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes
The ACCORD Study Group and ACCORD Eye Study Group.
N Engl J Med 2010;Jun 29:[Epub ahead of print].
Study Question: Do intensive glycemic control, combination therapy for dyslipidemia, and intensive blood pressure control limit the progression of diabetic retinopathy in persons with type 2 diabetes?
Clinical Predictors of Plaque Progression Despite Very Low Levels of Low-Density Lipoprotein Cholesterol
Bayturan O, Kapadia S, Nicholls SJ, et al.
J Am Coll Cardiol 2010;55:2736-2742.
Study Question: What risk factors are associated with coronary plaque growth in patients who have already achieved very low low-density lipoprotein cholesterol (LDL-C) levels?