Cardiac Origins of the Postural Orthostatic Tachycardia Syndrome
Fu Q, VanGundy TB, Galbreath M, et al.
J Am Coll Cardiol 2010;55:2858-2868.
Study Question: What is the mechanism of the postural orthostatic tachycardia syndrome (POTS)?
Serum Markers of Collagen Turnover Predict Future Shocks in Implantable Cardioverter-Defibrillator Recipients With Dilated Cardiomyopathy on Optimal Treatment
Kanoupakis EM, Manios EG, Kallergis EM, et al.
J Am Coll Cardiol 2010;55:2753-2759.
Study Question: Are markers of collagen turnover predictive of ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with nonischemic dilated cardiomyopathy (NIDC)?
Low-Dose Combination Therapy With Rosiglitazone and Metformin to Prevent Type 2 Diabetes Mellitus (CANOE trial): A Double-Blind Randomized Controlled Study
Zinman B, Harris SB, Neuman J, et al.
Lancet 2010;Jun 2:[Epub ahead of print].
Study Question: What is the effect of low-dose combination therapy with rosiglitazone and metformin on development of type 2 diabetes?
Tight Blood Pressure Control and Cardiovascular Outcomes Among Hypertensive Patients With Diabetes and Coronary Artery Disease
Cooper-DeHoff RM, Gong Y, Handberg EM, et al.
JAMA 2010;304:61-68.
Study Question: Does tight blood pressure (BP) control reduce cardiovascular (CV) outcomes among patient with diabetes and coronary artery disease (CAD)?
Coronary Microvascular Reactivity to Adenosine Predicts Adverse Outcome in Women Evaluated for Suspected Ischemia: Results From the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) Study
Pepine CJ, Anderson D, Sharaf BL, et al.
J Am Coll Cardiol 2010;55:2825-2832.
Study Question: Does coronary microvascular dysfunction predict adverse outcomes among women with signs and symptoms of ischemia?
Randomized Comparison of the Effects of Rosiglitazone vs. Placebo on Peak Integrated Cardiovascular Performance, Cardiac Structure, and Function
McGuire DK, Abdullah SM, See R, et al.
Eur Heart J 2010;Jul 2:[Epub ahead of print].
Study Question: The thiazolidinedione (TZD) drugs rosiglitazone and pioglitazone for type 2 diabetes mellitus (T2DM) cause peripheral edema, and less commonly, incident or worsening heart failure. What is the effect of rosiglitazone on cardiovascular performance and cardiac function?
Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study: Fractional Flow Reserve Versus Angiography in Multivessel Evaluation
Tonino PA, Fearon WF, De Bruyne B, et al.
J Am Coll Cardiol 2010;55:2816-2821.
Study Question: What is the relationship between angiographic and functional severity of coronary artery stenoses in the FAME (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation) study?
Predicting Survival in Pulmonary Arterial Hypertension. Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
Benza RL, Miller DP, Gomberg-Maitland M, et al.
Circulation 2010;122:164-172.
Study Question: Factors that determine survival in pulmonary arterial hypertension (PAH) drive clinical management. Can an effective quantitative survival prediction tool be established for research and clinical use?
Treatments, Trends, and Outcomes of Acute Myocardial Infarction and Percutaneous Coronary Intervention
Roe MT, Messenger JC, Weintraub WS, et al.
J Am Coll Cardiol 2010;56:254-263.
Perspective: The following are 10 points to remember about this report from the National Cardiovascular Data Registry (NCDR).
Carotid Artery Stenting With Emboli Protection Surveillance Study: Outcomes at 1 Year
Schreiber TL, Strickman N, Davis T, et al., on behalf of the CASES-PMS Investigators.
J Am Coll Cardiol 2010;56:49-57.
Study Question: What is the safety and efficacy of carotid artery stenting (CAS) for patients at high surgical risk, performed by physicians with varied experience?
Prognostic Significance of Myocardial Fibrosis Quantification by Histopathology and Magnetic Resonance Imaging in Patients With Severe Aortic Valve Disease
Azevedo CF, Nigri M, Higuchi M, et al.
J Am Coll Cardiol 2010;56:278-287.
Study Question: Does myocardial fibrosis (MF) in patients with severe aortic valve (AV) disease, assessed by histopathology or contrast-enhanced magnetic resonance imaging (ce-MRI), predict outcomes following surgical AV replacement?
The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6–HDL and LDL Treatment Strategies in Atherosclerosis): Final Results and the Impact of Medication Adherence, Dose, and Treatment Duration
Villines TC, Stanek EJ, Devine PJ, et al.
J Am Coll Cardiol 2010;55:2721-2726.
Study Question: ARBITER 6-HALTS (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6–HDL and LDL Treatment Strategies in Atherosclerosis) was terminated early on the basis of a prespecified interim analysis showing superiority of niacin over ezetimibe on change in carotid intima-media thickness (CIMT). Was there a relationship between cumulative exposures to the drugs and change in IMT?