Gender Differences in Clinical Outcome and Primary Prevention Defibrillator Benefit in Patients With Severe Left Ventricular Dysfunction: A Systematic Review and Meta-Analysis
Santangeli P, Pelargonio G, Dello Russo A, et al.
Heart Rhythm 2010;7:876-882.
Study Question: Do women sustain the same benefit as men following implantable cardioverter-defibrillator (ICD) implant for primary prevention in cardiomyopathy?
Effects of Cardiac Resynchronisation Therapy in Patients With Heart Failure Having a Narrow QRS Complex Enrolled in PROSPECT
Van Bommel RJ, Gorcsan J 3rd, Chung ES, et al.
Heart 2010;96:1107-1113.
Study Question: Will cardiac resynchronization therapy (CRT) benefit subjects with advanced heart failure who have a narrow QRS?
Prevalence of Fracture and Fragment Embolization of Bard Retrievable Vena Cava Filters and Clinical Implications Including Cardiac Perforation and Tamponade
Nicholson W, Nicholson WJ, Tolerico P, et al.
Arch Intern Med 2010;Aug 9:[Epub ahead of print].
Study Question: What is the prevalence of fracture and fragment embolization of Bard Recovery (first generation) and the Bard G2 (second generation) vena cava filters?
Predictors of Pregnancy Complications in Women With Congenital Heart Disease
Drenthen W, Boersma E, Balci, A, et al.
Eur Heart J 2010;Jun 28: [Epub ahead of print].
Study Question: What are the pregnancy outcomes of women with congenital heart disease?
Biological, Clinical and Population Relevance of 95 Loci for Blood Lipids
Teslovich TM, Musunuru K, Smith AV, et al.
Nature 2010;466:707-713.
Study Question: What common sequence variants in the human genome regulate blood lipid levels?
Prevalence and Clinical Significance of Aortic Root Dilation in Highly Trained Competitive Athletes
Pelliccia A, Di Paolo FM, De Blasiis E, et al.
Circulation 2010;122:698-706.
Study Question: What constitutes the upper limits of normal aortic root size, and what is the prevalence and significance of aortic dilation in a large cohort of competitive athletes?
Clopidogrel Loading Dose Adjustment According to Platelet Reactivity Monitoring in Patients Carrying the 2C19 2* Loss of Function Polymorphism
Bonello L, Armero S, Mokhtar OA, et al.
J Am Coll Cardiol 2010;Aug 11:[Epub ahead of print].
Study Question: What is the biological impact of a tailored clopidogrel loading dose (LD) according to platelet reactivity monitoring in carriers of the cytochrome (CYP) 2C19 2* loss-of-function polymorphism undergoing percutaneous coronary intervention (PCI) for an acute coronary syndrome?
Simplification of the Pulmonary Embolism Severity Index for Prognostication in Patients With Acute Symptomatic Pulmonary Embolism
Jiménez D, Aujesky D, Moores L, et al., on behalf of the RIETE Investigators.
Arch Intern Med 2010;170:1383-1389.
Study Question: Will a simplified version of the Pulmonary Embolism Severity Index (PESI) estimate the risk of 30-day mortality in patients with acute pulmonary embolism (PE) as well as the original tool?
Recommendations for the Use of Cardiac Troponin Measurement in Acute Cardiac Care
Thygesen K, Mair J, Katus H, et al., on behalf of the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care.
Eur Heart J 2010;Aug 3:[Epub ahead of print].
Perspective: The following are 10 points to remember from this article.
Exercise-Induced Changes in Degenerative Mitral Regurgitation
Magne J, Lancellotti P, Piérard LA.
J Am Coll Cardiol 2010;56:300-309.
Study Question: In patients with degenerative mitral regurgitation (MR), is there a relationship between exercise-induced changes in MR severity and either exercise systolic pulmonary artery pressure or symptom-free survival?
Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet: A Randomized Trial
Foster GD, Wyatt WR, Hill JO, et al.
Ann Intern Med 2010;153:147-157.
Study Question: Does a low-carbohydrate diet improve weight loss and metabolic parameters better than a low-fat diet?
A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones During the Menstrual Cycle: Findings From the BioCycle Study
Mumford SL, Schisterman EF, Siega-Riz AM, et al.
J Clin Endocrinol Metab 2010;Jun 9:[Epub ahead of print].
Study Question: Are endogenous estrogens associated with levels of serum lipoproteins across the menstrual cycle?