Extent of and Reasons for Nonuse of Implantable Cardioverter Defibrillator Devices in Clinical Practice Among Eligible Patients With Left Ventricular Systolic Dysfunction
LaPointe NM, Al-Khatib SM, Piccini JP, et al.
Circ Cardiovasc Qual Outcomes 2011;Feb 8:[Epub ahead of print].
Study Question: How often do eligible patients with heart failure (HF) not receive an implantable cardioverter-defibrillator (ICD) for the primary prevention of sudden cardiac death (SCD)?
Additional Ablation of Complex Fractionated Atrial Electrograms (CFAEs) After Pulmonary Vein Antral Isolation (PVAI) in Patients With Atrial Fibrillation: A Meta-Analysis
Li W, Bai Years, Zhang H, et al.
Circulation Arrhyth Electrophysiol 2011;Feb 8:[Epub ahead of print].
Study Question: Does ablation of complex fractionated atrial electrograms (CFAEs) improve the efficacy of radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) when performed after pulmonary vein antrum isolation (PVAI)?
Effects of Aspirin Responsiveness and Platelet Reactivity on Early Vein Graft Thrombosis After Coronary Artery Bypass Graft Surgery
Gluckman TJ, McLean RC, Schulman SP, et al.
J Am Coll Cardiol 2011;57:1069-1077.
Study Question: What parameters of platelet function following coronary artery bypass graft surgery (CABG) in patients on aspirin (ASA) are predictive of early bypass graft failure?
Association of Myocardial Enzyme Elevation and Survival Following Coronary Artery Bypass Graft Surgery
Domanski MJ, Mahaffey K, Hasselblad V, et al.
JAMA 2011;305:585-591.
Study Question: What is the relationship between peak post-coronary artery bypass grafting (CABG) elevation of biomarkers of myocardial damage and early, intermediate-, and long-term mortality?
Prenatal Ultrasound Screening of Congenital Heart Disease in an Unselected Population: A 21-Year Experience
Marek J, Tomek V, Škovránek J, Povýšilová V, Šamánek M.
Heart 2011;97:124-130.
Study Question: What is the prevalence of congenital heart disease and the impact of a national prenatal ultrasound screening program on outcomes in a discrete patient population?
Use of Intensive Insulin Therapy for the Management of Glycemic Control in Hospitalized Patients: A Clinical Practice Guideline From the American College of Physicians
Qaseem A, Humphrey LL, Chou R, Snow V, Shekelle P, on behalf of the Clinical Guidelines Committee of the American College of Physicians.
Ann Intern Med 2011;154:260-267.
Perspective: The following are 10 points to remember about these guidelines on the use of intensive insulin therapy (IIT) for the management of glycemic control in hospitalized patients
5-Year Follow-Up After Primary Percutaneous Coronary Intervention With a Paclitaxel-Eluting Stent Versus a Bare-Metal Stent in Acute ST-Segment Elevation Myocardial Infarction: A Follow-Up Study of the PASSION (Paclitaxel-Eluting Versus Conventional Stent in Myocardial Infarction With ST-Segment Elevation) Trial
Vink MA, Dirksen MT, Suttorp MJ, et al.
JACC Cardiovasc Interv 2011;4:24-29.
Study Question: What are the long-term outcomes of the PASSION (Paclitaxel-Eluting Versus Conventional Stent in Myocardial Infarction With ST-Segment Elevation) trial?
Timeliness of Tissue-Type Plasminogen Activator Therapy in Acute Ischemic Stroke: Patient Characteristics, Hospital Factors, and Outcomes Associated With Door-to-Needle Times Within 60 Minutes
Fonarow GC, Smith EE, Saver JL, et al.
Circulation 2011;123:750-758.
Study Question: What were the presenting characteristics of acute ischemic stroke patients treated with intravenous tissue-type plasminogen activator (tPA) within 3 hours of symptom onset in whom a door-to-needle time ≤60 minutes was achieved, hospital-level variation in door-to-needle times, in-hospital clinical outcomes, and temporal trends in timely thrombolytic care?
Relationship Between Risk Stratification at Admission and Treatment Effects of Early Invasive Management Following Fibrinolysis: Insights From the Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)
Yan AT, Yan RT, Cantor WJ, et al.
Eur Heart J 2011; Feb 8:[Epub ahead of print].
Study Question: Does risk stratification using the Global Registry of Acute Coronary Events (GRACE) influence effectiveness of early routine percutaneous coronary intervention (PCI) after fibrinolysis for ST-segment elevation myocardial infarction (STEMI)?
Compelling Evidence of Long-Term Outcomes in Pulmonary Arterial Hypertension? A Clinical Perspective
Gomberg-Maitland M, Dufton C, Oudiz RJ, Benza RL.
J Am Coll Cardiol 2011;57:1053-1061.
Conclusions: The following are 10 points to remember from a review of clinical trials in pulmonary arterial hypertension (PAH).
Quantitative Troponin and Death, Cardiogenic Shock, Cardiac Arrest and New Heart Failure in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (NSTE ACS): Insights From the Global Registry of Acute Coronary Events
Jolly SS, Shenkman H, Brieger D, et al., on behalf of the GRACE Investigators.
Heart 2011;97:197-202.
Study Question: What is the implication of the absolute level of troponin elevation in patients with non–ST-segment elevation acute coronary syndromes (NSTE-ACS)?
Cost-Utility of Aspirin and Proton Pump Inhibitors for Primary Prevention
Earnshaw SR, Scheiman J, Fendrick AM, McDade C, Pignone M.
Arch Intern Med 2011;171:218-225.
Study Question: What is the cost-utility of aspirin treatment with or without a proton pump inhibitor (PPI) for coronary heart disease (CHD) prevention among men at different risks for CHD and gastrointestinal (GI) bleeding?