[angio]

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4.2 Posology and method of administration
This product is for hospital use only. It should be administered by specialist physicians experienced in the management of acute coronary syndromes.

INTEGRILIN solution for infusion must be used in conjunction with INTEGRILIN solution for injection.
Concurrent administration of heparin is recommended unless this is contraindicated for reasons such as a history of thrombocytopenia associated with use of heparin (see 'Heparin administration', section 4.4). INTEGRILIN is also intended for concurrent use with acetylsalicylic acid, as it is part of standard management of patients with acute coronary syndromes, unless its use is contraindicated.

Posology
Adults ( 18 years of age) presenting with unstable angina (UA) or non-Q-wave myocardial infarction (NQMI)
The recommended dosage is an intravenous bolus of 180 microgram/kg administered as soon as possible following diagnosis, followed by a continuous infusion of 2.0 microgram/kg/min for up to 72 hours, until initiation of coronary artery bypass graft (CABG) surgery, or until discharge from the hospital (whichever occurs first). If Percutaneous Coronary Intervention (PCI) is performed during eptifibatide therapy, continue the infusion for 20-24 hours post-PCI for an overall maximum duration of therapy of 96 hours.

Emergency or semi-elective surgery
If the patient requires emergency or urgent cardiac surgery during the course of eptifibatide therapy, terminate the infusion immediately. If the patient requires semi-elective surgery, stop the eptifibatide infusion at an appropriate time to allow time for platelet function to return towards normal.

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Сообщение от Gilarov

Даешь плавикс интракоронарно!!!!

Шутки, шутками, а я не раз видел в судне и на полу в операционной злосчастные 8 едва растворившихся таблеток, уже далеко не такого гламурного цвета и вида. Особенно это касается обезболенных морфином. Посему иметь инъекционный клопидогрель было бы весьма неплохо. ИМХО, для метаболизма в печени способ попадания препарата не через портальную систему не столь уж важен (хотя кто знает)