[Chevychelov]

Ninety percent of patients with coronary heart disease (CHD) have
at least 1 atherosclerotic risk factor (4). Approximately half
of all coronary deaths are not preceded by cardiac symptoms
or diagnoses (5). One aim of this guideline is to provide an
evidence-based approach to risk assessment in an effort to
lower this high burden of coronary deaths in asymptomatic
adults.

CHD has a long asymptomatic latent period, which
provides an opportunity for early preventive interventions.
Atherosclerosis begins in childhood and progresses into
adulthood due to multiple coronary risk factors such as
unfavorable levels of blood lipids, blood pressure, body
weight and body fat, smoking, diabetes, and genetic predisposition
(8–10). The lifetime risk of CHD and its various
manifestations has been calculated for the Framingham
Heart Study population at different ages.

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