Главный вопрос - какой у вас показатель клиренса креатинина?
Пациентам, находящимся на хроническом диализе, в том числе и перитонеальном, энтекавир назначается в стандартной дозе (0.5)
1 раз в неделю .
Цитата:
Entecavir
Dosing adjustment in renal impairment:
Children and Adolescents: There are no dosage adjustments provided in the manufacturer's labeling; insufficient data to recommend a specific dose adjustment in pediatric patients with renal impairment; a reduction in the dose or an increase in the dosing interval similar to adjustments for adults should be considered.
Adults: Daily dosage regimen preferred:
CrCl ≥50 mL/minute: No adjustment necessary
CrCl 30 to 49 mL/minute: Administer 50% of usual dose once daily or administer the normal dose every 48 hours
CrCl 10 to 29 mL/minute: Administer 30% of usual dose once daily or administer the normal dose every 72 hours
CrCl <10 mL/minute: Administer 10% of usual dose once daily or administer the normal dose every 7 days
Hemodialysis and peritoneal dialysis (CAPD): Minimally removed by hemodialysis (13% over 4 hours) and CAPD (0.3% over 7 days): Administer 10% of usual dose once daily or administer the normal dose every 7 days; administer after hemodialysis
|
[
Ссылки доступны только зарегистрированным пользователям ]