A total of 71 677 veterans with IDA (63 202 male [88.2%] and 8475 female [11.8%]; mean [SD] age, 68.5 [13.1] years), including 47 201 with NKF and 24 476 with CKD, were identifed. In patients with NKF in the daily group, hemoglobin increased from baseline (estimated per-30-day difference [SE], 0.27 [0.00] g/dL; P < .001).
Patients were classified into 3 groups based on their oral iron dosing schedule: daily (once a day), multiple doses per day (MDD; ≥2 times per day), or alternate-day dose (ADD).
In comparison with the daily group, hemoglobin increased more in the MDD group (estimated per-30-day difference [SE], 0.08 [0.03] g/dL; P < .001), but no difference was noted in the ADD group (estimated per-30-day difference [SE], −0.01 [0.01] g/dL; P = .38).
Among patients with NKF, the adjusted mean increase in hemoglobin was
1.03 g/dL (95% CI, 1.01-1.06 g/dL) for those in the daily group,
1.38 g/dL (95% CI, 1.36-1.40 g/dL) for those in the MDD group, and
0.93 g/dL (95% CI, 0.84-1.02 g/dL) for those in the ADD group at 90 days.
Among patients with CKD, the adjusted mean increase in hemoglobin was
0.71 g/dL (95% CI, 0.68-0.73 g/dL) for those in the daily group,
0.99 g/dL (95% CI, 0.97-1.01 g/dL) for those in the MDD group, and
0.62 g/dL (95% CI, 0.52-0.73 g/dL) for those in the ADD group at 90 days.
Optimal Oral Iron Therapy for Iron Deficiency Anemia Among US Veterans
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