[Dr.Vad]

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Infrequent symptoms in non-anemic patients with iron deficiency

Exceptional fatigue lasting several days after mild to moderate physical activity
Severe headache and treatment-resistant migraine
Severe memory lapses forcing the patient to take rigorous written notes of everything
Weight loss (About 10% of patients lose weight, 60% gain weight and in 30% the weight remains stable)
Muscle tension and cramps unresponsive to muscle relaxants and massage
Therapy-resistant heavy menstruation
Snoring and sleep apnea, both of which resolve when iron deficiency is corrected
Inability to get sun tanning which is reversed when iron stores have been repleted
Nausea and loss of appetite
Plantar fasciitis
Bruxism

Numbness or dysesthesia (pins and needles) of the extremities on one side of face or body, which may require ruling out of multiple sclerosis
Color vision disturbances and blurred vision/inability to focus
Childlessness and recurrent miscarriages
Objectively detected hot/burning skin without fever
Severe heart rate disturbances leading even to syncope at rest or during exercise
Hypokalemia, not associated with high blood pressure or hormonal changes and unresponsive to potassium substitution and spironolactone
Tongue pain
Urticaria
Severe sleeping disturbances / insomnia, which may lead to psychiatric care
Severe depression resistant to treatment including electroconvulsive therapy
Transient swelling of joints without inflammation

Iron Deficiency in the Absence of Anemia - A Common, Complex and Challenging Disease to Treat
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