пробиотики улучшают переносимость приема железа внутрь и повышают гемоглобин и ферритин:
IRT-Pro group, when compared to IRT-only group, experienced significantly lower rates of gastrointestinal intolerance over the course of IRT (13.0% vs. 46.5%, p<0.001) and treatment discontinuation within the first 30 days (4% vs. 16%, p<0.001).
At 3rd month of therapy, IRT-Pro vs. IRT-only group had significantly higher serum levels for iron (76.0(51.0-96.0) vs. 60.0(43.0-70.0) µg/dL, p<0.001) and transferrin saturation (20.1(12.5-28.5) vs. 14.5(10.5-19.0) %, p<0.001) and higher change from baseline hemoglobin (9(3-13) vs. 4(-1-11) g/L, p<0.001) levels.
Use of Lactobacillus plantarum 299v probiotic supplementation during the first 30 days of IRT in IDA patients significantly reduces the gastrointestinal burden of IRT (particularly abdominal pain and bloating), the likelihood of intolerance development (by ∼3 times) and treatment discontinuation (by∼5 times), as accompanied with improved serum hemoglobin levels and serum iron...
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Br J Nutr. 2024 Nov 4:1-22.
Improved gastrointestinal tolerance and iron status via probiotic use in iron deficiency anemia patients initiating oral iron replacement: A randomized controlled trial
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