если о причине повышения у пациента, то да:
As total Testosterone increases, we tend to see an increase in SHBG. Conversely, with low total testosterone, we tend to see a decrease in SHBG. This is likely to maintain a more stable level of free Testosterone.
Если о причинах повышения ГСПГ, то кроме анорексии:
Hyperthyroidism is another cause, where thyroid hormones are known to increase SHBG by directly altering the production of SHBG in the hepatocytes (liver cells), likely due to thyroid hormones increasing gene expression of HNF-4α within the liver, where HNF-4α increases SHBG production. This also provides some evidence for why anorexia may contribute to elevate SHBG. For those curious what HNF-4α does, well it plays a very key role in the transcriptional activity of the SHBG promoter region 8 – as its activity increases, so does SHBG production.
We also see high SHBG in those with liver disease, due to improper hepatocyte function, those with growth hormone deficiency, the elderly/ageing, and genetic mutations in the SHBG gene.
хороший обзор по теме был недавно опубликован:
Accurate measurement of total and free testosterone levels for the diagnosis of androgen disorders
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