[Maltsev]

Effect of Long-Term Clopidogrel Treatment on Platelet Function and Inflammation in Patients Undergoing Coronary Arterial Stenting

Publication: AJC 103(11):1546-1550 Authors: MJ Antonino, E Mahla, KP Bliden, et al.

Platelet reactivity to adenosine diphosphate and inflammation markers were measured in 110 consecutive patients (69 clopidogrel-naive patients and 41 patients receiving long-term clopidogrel therapy for >6 months) before nonemergent stenting by turbidimetric aggregometry and flow cytometry and multianalyte profiling, respectively. All patients were treated with aspirin. Prestenting adenosine diphosphate–induced platelet aggregation, P-selectin, and activated glycoprotein IIb/IIIa expression were lower in patients receiving long-term clopidogrel therapy compared with the clopidogrel-naive group (p <0.001), accompanied by lower levels of selected inflammation markers (p ≤0.05). Additionally, there were strong correlations between platelet aggregation and flow cytometric measurements (p ≤0.04) and between specific inflammation markers (p ≤0.02).

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С Уважением,
Мальцев А.А.