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dose delivery (defined as the effectively delivered chemotherapy dose considering all reductions, omissions and withdrawn patients)
Dose delivery differed significantly between arms with 74.6% (95% CI 62.5–84.5) for CPx versus 20% (95% CI 11.1–31.8) for CVb (P < 0.0001). In the CPx arm, cisplatin delivery was 90% of planned with 271 (range 75–300) mg/m2 mean dose and 23 (range 6–25) mg/m2/week mean dose intensity, and
pemetrexed delivery was 90% of planned with 1810 (range 500–2000) mg/m2 mean dose and 151 (range 42–167) mg/m2/week mean dose intensity.
Thus, the reduction of toxicity, improvements of dose delivery and of patient compliance remain important issues to be addressed in the adjuvant treatment
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18.05.2013, 22:39
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