|
#16
12.08.2011, 14:17
|
|||
|
|||
|
The incidence of leukotrichia in segmental vitiligo: implication of poor response to medical treatment
[Ссылки доступны только зарегистрированным пользователям ] [Ссылки доступны только зарегистрированным пользователям ] Conclusions Based on our results, a very high percentage of patients with segmental vitiligo may be associated with leukotrichia. Many white hairs in segmental vitiligo may contribute to the lack of response with medical treatment. The examination of hair color with a digital microscope may be very useful for the prediction of treatment outcome and decision of treatment modalities. - финастерид и риск рака легких; еще конечно потребуются более достоверные данные, но для пациентов с уже имеющимся риском (курение в том числе) следует иметь ввиду [Ссылки доступны только зарегистрированным пользователям ] The effect of a 1550*nm fractional erbium–glass laser in female pattern hair loss [Ссылки доступны только зарегистрированным пользователям ] Conclusion A 1550*nm fractional erbium–glass laser irradiation may be an effective and safe treatment option for women with female pattern hair loss. |
|
#17
08.10.2011, 01:02
|
|||
|
|||
|
White piedra of scalp hair by Trichosporon inkin
[Ссылки доступны только зарегистрированным пользователям ] Microsporum canis tinea capitis in a centenarian patient [Ссылки доступны только зарегистрированным пользователям ] Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study [Ссылки доступны только зарегистрированным пользователям ] Conclusion Bimatoprost 0.03% was found to be effective at enhancing eyelashes in adults with a very good safety profile. Androgenetic alopecia as an early marker of benign prostatic hyperplasia[Ссылки доступны только зарегистрированным пользователям ] Conclusion There is a relationship between the presence of AGA and prostate growth-associated urinary symptoms, likely attributable to their pathophysiological similarity. This study suggests that early-onset AGA may be an early marker of urinary/prostatic symptomatology. Future studies may clarify whether treatment of patients with AGA may benefit the concomitant benign prostatic hypertrophy, which would be present at an earlier stage in its natural evolution. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia[Ссылки доступны только зарегистрированным пользователям ] Conclusions Latanoprost significantly increased hair density (terminal and vellus hairs) at 24 weeks compared with baseline and the placebo-treated area. Latanoprost could be useful in stimulating hair follicle activity and treating hair loss. Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata [Ссылки доступны только зарегистрированным пользователям ] Conclusion: Antibodies against TH can be present in patients with AA unrelated to APS1. Humoral immune responses against tyrosinase, TRP-1, TRP-2, gp100 and MelanA are not prevalent in AA patients. Overall, a dominant melanocyte-specific B cell autoantigen in AA has yet to be identified. Kawasaki Disease and Alopecia Areata: Coincidence or a True Association? [Ссылки доступны только зарегистрированным пользователям ] Familial Androgenetic Alopecia in Siblings with Normal Endocrinological Status [Ссылки доступны только зарегистрированным пользователям ] Abstract: Androgenetic alopecia (AGA) is the most common type of hair loss in adults, but it has been rarely reported in children. We report two cases of AGA in two siblings, aged 6 and 8, whose mother had the same condition, without any association with other skin diseases or abnormalities in endocrinologic examinations. Temporal triangular alopecia: Trichoscopic diagnosis[Ссылки доступны только зарегистрированным пользователям ] Temporal triangular alopecia (TTA) is circumscribed, non-cicatricial, non-inflammatory hair loss, which is confined to the frontotemporal region.1 TTA is referred to also as congenital triangular alopecia. However, more than half of the cases (55.8%) have been noticed at the age of 2–9*years and only 3.8% in adulthood while 36.5% were found at birth.1 Recently, it has been reported that scalp dermoscopy, also called as trichoscopy,2,3 is useful for diagnosis of TTA without taking biopsy.4 We report here two cases of TTA diagnosed using trichoscopy. Figure*1. Clinical and trichoscopic appearances of case 1. (a) Temporal hair loss was seen. (b) Trichoscopically normal follicular openings with vellus hairs surrounded by normal terminal hair area was observed. Because the main clinical feature of TTA is vellus hair and hair follicle miniaturization, which is similar to androgenetic alopecia, we are now considering treatment with topical minoxidil. Therefore, we propose here the diagnostic criteria for TTA as follows; (i) triangular or lancet-shaped patch of alopecia involving frontotemporal scalp; (ii) trichoscopically normal follicular openings with vellus hairs surrounded by normal terminal hair area; (iii) trichoscopically no broken hairs, tapering hairs, black dots, yellow dots and orifice loss; and (iv) persistent without significant hair regrowth for 6*months after clinically or trichoscopically confirming the existence of vellus hairs. Utility of dermoscopy in alopecia areata [Ссылки доступны только зарегистрированным пользователям ] Conclusions: The most common dermoscopic finding of AA in our study was yellow dots, followed by black dots, broken hairs, short vellus hair and tapering hairs. Dermoscopic findings were not affected by the type of AA or the severity of the disease. Dermoscopic findings in alopecia areata [Ссылки доступны только зарегистрированным пользователям ] Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia [Ссылки доступны только зарегистрированным пользователям ] Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia [Ссылки доступны только зарегистрированным пользователям ] Conclusions* Our survey results suggest that there is a high prevalence of central hair loss among African American women. Hair styles causing traction as well as inflammation in the form of bacterial infection may be contributing to the development of CCCA. The increase in diabetes mellitus type 2 among those with CCCA is in line with the recent theory that cicatricial alopecia may be a manifestation of metabolic dysregulation. Human hair follicle: reservoir function and selective targeting [Ссылки доступны только зарегистрированным пользователям ] Penetration of topical compounds may occur via hair follicles. - The follicular infundibulum increases the surface area and serves as a reservoir. - Follicular delivery may help to treat localized inflammatory reactions with reduced systemic side-effects, and to develop new strategies in the treatment of scalp diseases. What does this study add? - Provides a review on the in vitro and in vivo methods for studying the hair follicle structure, transfollicular penetration pathways and follicular delivery. The antifungal mechanism of action of zinc pyrithione [Ссылки доступны только зарегистрированным пользователям ] Conclusions The molecular basis for the antifungal activity of the commonly used active ZPT has been elucidated, more than 50*years since its introduction, as utilizing a copper toxicity mechanism that targets critical iron–sulphur proteins. Little is known of the antifungal mechanism of action of zinc pyrithione (ZPT). Previous reports indicated that ZPT starves cells for iron and, at high doses, depolarizes membranes. This study demonstrates for the first time that ZPT inhibits fungal growth through copper import and damage to iron–sulphur proteins. Improvement In Scalp Hair Growth In Androgen-Deficient Women Treated With Testosterone: A Questionnaire Study [Ссылки доступны только зарегистрированным пользователям ] Conclusions: Subcutaneous testosterone therapy was found to have a beneficial effect on scalp hair growth in female patients treated for symptoms of androgen deficiency. We propose this is due to an anabolic of testosterone on hair growth. The fact that no subject complained of hair loss as a result of treatment casts doubt on the presumed role of testosterone in driving female scalp hair loss. These results need to be confirmed by formal measurements of hair growth. |
|
#18
17.12.2011, 23:30
|
|||
|
|||
|
ГА
Extensive alopecia areata: Not necessarily recalcitrant to therapy![Ссылки доступны только зарегистрированным пользователям ]
Conclusion: A combination therapy of oral steroid minipulse with topical anthralin and minoxidil acts synergistically, being effective as well as safe in treatment-resistant, extensive, long-standing alopecia areata. Steroids have been useful in the treatment of alopecia areata. However, daily doses of steroids have significant treatment-related side effects. On the other hand, alternate day steroids or pulsed dosing may be inadequate. Therefore, the combination of topical minoxidil with anthralin along with oral mini-pulses of systemic steroid used in our study yields effective response, while being safe at the same time. Maintenance of cosmetic response can easily be achieved with only topical minoxidil and anthralin while gradually tapering and finally discontinuing oral steroids. We propose that this combination therapy would provide a new approach in treatment-resistant, extensive, long-standing alopecia areata. All patients were started on oral betamethasone mini-pulse (0.1 mg/kg/body weight on two consecutive days per week) along with 2-5% topical minoxidil and 1.15% anthralin cream. Oral minipulse was continued till the patient achieved a cosmetic response and then it was maintained for 6 to 9 months depending on the response attained. The oral minipulse was gradually tapered by 20% every three weekly after cosmetic response and then stopped. If response was not seen in six months then oral steroids were stopped. One milliliter of topical minoxidil was applied to the affected scalp and then was reapplied 12 h later. Anthralin cream was applied daily in the night 2 h after the last application of minoxidil for 10?min (contact time) initially, and thereafter the contact time was escalated every three weekly till mild erythema was seen. The contact time responsible for the mild erythema was maintained throughout the study period. Maximum contact time achieved was 1 h. The patients were instructed to clean the treatment area with mineral oil and water after the specified contact time. Topical minoxidil and anthralin was continued as maintenance therapy after stopping oral steroids. Maintenance therapy included tapering the number of applications of topical minoxidil to once a day, as well as anthralin to once or twice weekly. Practicality in using diphenyl cyclo propenone for alopecia areata[Ссылки доступны только зарегистрированным пользователям ] Diphenyl cyclo propenone (DPCP) is used as a topical immunomodulator in alopecia areata. DPCP was first used by Happle et al. for alopecia areata. [1] It is a potent contact allergen in humans and animals; 98-99% of the cases of alopecia areata can be sensitized on the scalp skin. [2] Although its use has been increasing of late, the process of procuring, dilution and storage at a particular concentration is cumbersome and limits its wide use. This short communication aims to make the DPCP preparation and application easy for the readers. The common adverse effects after DPCP applications are local eczema with blistering, regional lymphadenopathy and contact urticaria. [3],[4] Rare adverse effects include an erythema multiforme-like reaction, hyperpigmentation, hypopigmentation and vitiligo. Alteration in Hair Texture Following Regrowth in Alopecia Areata[Ссылки доступны только зарегистрированным пользователям ] Conclusions The precipitating factor for a change in hair texture in alopecia areata may be a result of treatment, pathophysiologic changes, or a combination of both. Whether the change is triggered at the level of stem cell differentiation, by cytokine or hormonal influences, gene expression during hair follicle development, a combination of all of these, or an unknown cause is a question that remains to be answered. |
|
#19
17.12.2011, 23:31
|
|||
|
|||
|
- важная роль липидов в структуре волос(подобно коже)
[Ссылки доступны только зарегистрированным пользователям ] Integral hair lipid in human hair follicle Connubial Androgenetic Alopecia [Ссылки доступны только зарегистрированным пользователям ] A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. [Ссылки доступны только зарегистрированным пользователям ] CONCLUSIONS: Once-daily 5% MTF is noninferior and as effective for stimulating hair growth as twice-daily 2% MTS in women with androgenetic alopecia and is associated with several aesthetic and practical advantages. Darier's Disease Misdiagnosed as Severe Seborrheic Dermatitis [Ссылки доступны только зарегистрированным пользователям ] Darier's disease is commonly misdiagnosed as seborrheic dermatitis or eczema. Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect [Ссылки доступны только зарегистрированным пользователям ] 'Tracing Elements' in hair [Ссылки доступны только зарегистрированным пользователям ] Hard facts about loose stools - Massive alopecia in Gloriosa superba poisoning [Ссылки доступны только зарегистрированным пользователям ] Elevated yellow nodule over the scalp in a middle-aged man [Ссылки доступны только зарегистрированным пользователям ] - "псевдогниды" Hair casts or pseudonits [Ссылки доступны только зарегистрированным пользователям ] Comparison of true nits and pseudonits [Ссылки доступны только зарегистрированным пользователям ] Bubble hair and other acquired hair shaft anomalies due to hot ironing on wet hair [Ссылки доступны только зарегистрированным пользователям ] Nevoid hypertrichosis: Case report with review of the literature [Ссылки доступны только зарегистрированным пользователям ] Atrichia with papular lesions [Ссылки доступны только зарегистрированным пользователям ] Silvery hair syndrome in two cousins: Chediak-Higashi syndrome vs griscelli syndrome, with rare associations [Ссылки доступны только зарегистрированным пользователям ] There are several reports in the literature, on CHS and GS, with marked variations in clinical presentation, investigative findings, and mean age of diagnosis and survival. There have been individual case reports with association of other feature like partial oculocutaneous albinism and sensory neural deafness. To the best of our knowledge, there are no previous reports in English literature suggesting CHS with Erythema multiforme and sensory neural deafness Trichorrhexis nodosa with nail dystrophy: Diagnosis by dermoscopy [Ссылки доступны только зарегистрированным пользователям ] An unusual case report of rapunzel syndrome trichobezoar in a 3-year-old boy [Ссылки доступны только зарегистрированным пользователям ] Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: A case report and immunohistochemical study [Ссылки доступны только зарегистрированным пользователям ] - психодерматология/"психотрихология" Treatment of pseudofolliculitis in trichotillomania improves outcome[Ссылки доступны только зарегистрированным пользователям ] The psychiatric comorbidities of trichotillomania have been well documented. [2],[5],[6],[7] These include obsessive compulsive disorder, depression, and anxiety. This is the first case series describing pseudofolliculitis associated with trichotillomania. We feel that this entity is under-recognised by clinicians. As the affected patients in our series ranged in age from 7 to 46 years and spanned three different races, the true prevalence of pseudofolliculitis amongst patients with trichotillomania is likely significant. Identifying features included the presence of scalp pruritus, papules, excoriations and in some cases, distorted and ingrown hairs. However, not all patients were forthcoming with their symptoms of itch; this same patient also did not realise she had scalp papules. If left untreated, patients can harbour symptoms for an extended period of time as Case 3 and 5 illustrate, with considerable pruritus and hairloss. It is noteworthy that these patients improved on a simple regimen of topical steroid, antipruritic shampoo, topical or oral antibiotics. None were placed on psychotropic medications or seen by a psychiatrist. However, patients were taught habit reversal techniques and counseled on stress management strategies by dermatologists in a centre with a psychodermatology unit. The pathogenesis of trichotillomania is multifactorial and complex. [2],[5],[8] Patients with trichotillomania pull their hairs either due to a habit tic or an obsessive compulsive need to relieve a perceived or inorganic source of follicular itch. In certain cases, rubbing of the hair or trichoteiromania [9] may occur either in isolation or concurrently with trichotillomania. Pseudofolliculitis develops as a result of a foreign body reaction to the sharp ends of the new, ingrown and coiled hairs. [3] While it is unclear whether the inflammatory scalp papules preceded or followed from the hair pulling, we postulate that the inwardly curving, regrowing hairs from repeated pulling incite a local inflammatory reaction, culminating in a vicious cycle of itching, scratching, and pulling. Treating the pseudofolliculitis that is secondary to the trichotillomania or trichoteiromania would remove an additional source of organic scalp itch, thereby allowing patients to concentrate on behaviour modification techniques for treatment of the trichotillomania itself. Prospective studies are required to assess the prevalence, relapse rate, psychiatric comorbidities, and long term prognosis of this condition. Trichotillomania-induced pseudofolliculitis is a newly described condition. Treatment of the pseudofolliculitis with topical steroids, oral, or topical antibiotics improves hair regrowth. The role of bimatoprost eyelash gel in chemotherapy-induced madarosis: An analysis of efficacy and safety[Ссылки доступны только зарегистрированным пользователям ] Bimatoprost eyelash gel increased eyelash length in the treated eyelids. There was a trend for increase in the rate of eyelash growth in comparison to control eyelids. There was a significant increase in the number of eyelashes in both treatment and fellow eyelids overtime. There was a notable difference in the eyelash pigment of treated eyelashes compared to fellow eyelashes at months 1 and 2. Eyelash thickness was significantly greater at months 2-3 in treated eyelashes versus control eyelid. Patients were pleased with the results achieved by bimatoprost eyelash gel, including the minimal side effects observed. A role of both functional and cosmetic benefits may be achieved with use of bimatoprost eyelash gel. Further investigation with a multicenter, blinded, randomized, controlled trial is needed to explore the long-term results. Forearm pilomatricoma with extensive ossification [Ссылки доступны только зарегистрированным пользователям ] Human hair - An evolutionary relic? [Ссылки доступны только зарегистрированным пользователям ] Coexistence of acquired hypertrichosis and scalp alopecia in a patient with infiltrating ductal carcinoma [Ссылки доступны только зарегистрированным пользователям ] |
Линейный вид
