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![]() A longitudinal study of more than 16600 patients
in the cardiovascular arm of the UK General Practice Research Database found that higher dose statins taken for at least two years are associated with significant reductions in clinically important outcomes in osteoarthritis (Journal of General Internal Medicine 2013, doi:10.1007/ s11606-013-2382-8). Estimated reductions in osteoarthritis outcome were 18% after two years and 40% after four years in people taking high dose statins compared with non-statin users. Biological modification of osteoarthritis seems a plausible explanation, and abnormal lipid metabolism might be a a causal factor in the pathogenesis of the disease. |