Железодефицитные новости

[Dr.Vad]

Вегетарианская и даже полувегетарианская диета негативно влияет на баланс железа в организме - вегетарианцы должны проверять свой ферритин и при необходимости - корректировать его: мужчины в особенной опасности:

The meta-analysis which combined data of 24 cross-sectional studies showed that adult vegetarians have significantly lower serum ferritin levels than their non-vegetarian controls (-29.71 µg/L, 95% CI [-39.69, -19.73]). Inclusion of semi-vegetarian diets did not change the results considerably (-23.27 µg/L, 95% CI [-29.77, -16.76]). The effects were more pronounced in men (-61.88 µg/L, 95% CI [-85.59, -38.17]) than in both premenopausal women (-17.70 μg/L, 95% CI [-29.80, -5.60]) and all women (-13.50 μg/L, 95% CI [-22.96, -4.04]), respectively.
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Crit Rev Food Sci Nutr. 2016 Nov 23:1-16.
The effect of vegetarian diets on iron status in adults: A systematic review and meta-analysis.

[Dr.Vad]

Индусы показали, что если беременным женщинам давать железо и фолиевую, то у них повышается уровень железа, цинка и меди в крови, а концентрация селена и потенциально токсичного для плода марганца снижается, подробнее

Indian J Clin Biochem. 2018 Jan;33(1):31-37.
Study on Impact of Iron and Folic Acid on the Plasma Trace Minerals in Pregnant Anemic Women.
Tiwari AKM и соавт.

[Dr.Vad]

...serum ferritin levels were significantly lower in ADHD children (children with ADHD = 1560, HCs = 4691, Hedges’ g = −0.246, p = 0.013), but no significant difference in serum iron or transferrin levels. In addition, the severity of ADHD was significantly higher in the children with ID than those without ID (with ID = 79, without ID = 76, Hedges’ g = 0.888, p = 0.002), and there was a significant association between ADHD and ID (OR = 1.636, p = 0.031).
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Peripheral iron levels in children with attention-deficit hyperactivity disorder: a systematic review and meta-analysis.
[Ссылки доступны только зарегистрированным пользователям ]

[Dr.Vad]

Дефицит железа и витамина Д у спортсменок Польши - чем выраженнее ЖД, тем выше риск дефицита витамина Д и наоборот:

The Association between Iron and Vitamin D Status in Female Elite Athletes
[Ссылки доступны только зарегистрированным пользователям ]

[Dr.Vad]

Оценка безопасности в/в пр-тов железа (монофер против феринджекта) на примере лечения 2 тысяч пациенток - гипофосфатемия развивалась у каждой третьей на фоне феринджекта:

This randomized, multicenter, double-blind clinical trial compared the safety and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of hypersensitivity reactions and hypotension as the primary end point. Patients with iron deficiency anemia of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1.02 g and 1.50 g. Composite incidences of moderate-to-severe hypersensitivity reactions, including anaphylaxis, or moderate-to-severe hypotension from baseline to week 5 (primary safety end point) were 0.6% and 0.7% in the ferumoxytol and FCM groups, respectively, with ferumoxytol noninferior to FCM. No anaphylaxis was reported in either group. The secondary safety end point of incidences of moderate-to-severe hypersensitivity reactions, including anaphylaxis, serious cardiovascular events, and death from baseline to week 5 were 1.3% and 2.0% in the ferumoxytol and FCM groups, respectively (noninferiority test P < .0001). Least-squares mean changes in hemoglobin at week 5 were 1.4 g/dL and 1.6 g/dL in the ferumoxytol and FCM groups, respectively (noninferiority test P < .0001). Incidence of hypophosphatemia was 0.4% for ferumoxytol and 38.7% for FCM.
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Am J Hematol. 2018 Feb 8.
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial.

[Dr.Vad]

Железо в лечении синдрома беспокойных ног - рекомендации международного консенсуса:

Ferric carboxymaltose (1000 mg) is effective for treating moderate to severe RLS in those with serum ferritin <300 μg/l and could be used as first-line treatment for RLS in adults. Oral iron (65 mg elemental iron) is possibly effective for treating RLS in those with serum ferritin ≤75 μg/l. There is insufficient evidence to make conclusions on the efficacy of oral iron or IV iron in children.
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Sleep Med. 2018 Jan;41:27-44.
Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report.
Allen RP & International Restless Legs Syndrome Study Group (IRLSSG).

[Dr.Vad]

Итальянские доктора показали, что у недоношенных детей (менее 32 недель) назначение железа бисглицината в дозе 0.75 мг/кг было эквивалентным 3 мг/кг сульфата по лечению ЖДА вместе с эритропоэтином:
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Curr Pediatr Rev. 2018 Jan 23.
Iron supplementation with iron sulfate versus iron bisglycinate chelate in preterm newborns.