Железодефицитные новости

[Dr.Vad]

Как незначительная недоношенность и железодефицит матери негативно влияют на запасы железа у плода: ферритин у плода был 96 при ЖД у матери и не особенно менялся на сроке 37-41 недели; тогда как ферритин был 116 у плода без дефицита железа и отмечался его рост с 37 до почти 39 недель беременности, после чего оставался таким же до 41 недели:

J Perinatol. 2018 Jun 8. doi: 10.1038/s41372-018-0140-9
Inadequate iron stores in early term neonates.
Hua Y и соавт.

[Dr.Vad]

ЖД, анемия и дефицит В12 негативно влияет на поведенческие реакции у мальчиков-подростков, но не у девочек:

We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia. Behavior problems were assessed with the Youth Self-Report questionnaire after a median 6.2 y of follow-up.
Mean ± SD externalizing and internalizing problems scores were 52.6 ± 9.6 and 53.8 ± 9.9, respectively. Among boys, middle-childhood ID, anemia, and low plasma vitamin B12 were associated with 5.9 (95% CI: 1.0, 10.7), 6.6 (95% CI: 1.9, 11.3), and 2.7 (95% CI: 0.4, 4.9) units higher mean externalizing problems scores in adolescence, respectively-after adjustment for baseline age, time spent watching television or playing video games, mother's height, and socioeconomic status. Also in boys, ID was related to an adjusted 6.4 (95% CI: 1.2, 11.6) units higher mean internalizing problems score. There were no associations among girls.
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J Nutr. 2018 Apr 20.
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the Bogotá School Children Cohort.
Robinson SL и соавт.

[Dr.Vad]

Ассоциация ЖДА с менструальной мигренью:

The migraine subgroups selected were as follows: (1) pure menstrual migraine (PMM) or menstrually related migraine (MRM) and (2) migraine not associated with menses (MNAM).
IDA was more common in patients with migraine than controls (21.7% vs 12.9%, P = 0.02). There was no association between IDA and tension-type headache (15.9% vs 12.9%, P = 0.43). Family history of migraine (P < 0.001) and IDA (P = 0.03) were significant factors in the model of migraine. Age (P = 0.009), family history of migraine (P < 0.001), and IDA (P = 0.018) were significant factors in the model of PMM/MRM. Only family history of migraine (P < 0.001) was significant in the model of MNAM.
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Pain Med. 2016 Mar;17(3):596-605.
Iron Deficiency Anemia Is Associated with Menstrual Migraine: A Case-Control Study.

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Of all IDA patients, 79.5 % defined headache at any time of their life. In addition, 36.2 % of all IDA patients defined the criteria for migraine. IDA patients with migraine were more frequently smokers and had significantly lower hemoglobin and mean corpuscular volume values (p values < 0.05). The IDA group with migraine had significantly higher mean anxiety score (p = 0.046) and headache-related QoL disturbance score (p = 0.021) than the IDA group without migraine. Migraine patients with aura had lower hemoglobin values (p = 0.02), higher depression scores (p = 0.005), and higher migraine-related QoL disturbance scores than others.
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Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):576-580.
Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?
Pamuk GE и соавт.

[Dr.Vad]

Стресс у матери во время беременности повышает риск ЖД у новорожденного в 3.5 раза:

Maternal recall of distress and health concerns during pregnancy correlated with cord blood ZnPP/H indices (r = 0.21, P < .01), even in the absence of major traumatic events... At 1 year, 24% of infants who were breastfed had moderate iron deficiency (plasma ferritin <12 µg/L). Higher cord blood ZnPP/H was predictive of this moderate iron deficiency (95% CI 1.26-1.47, P = .007). When coincident with maternal reports of gestational stress, the likelihood of low plasma ferritin at 1 year increased 3.6-fold in breastfed infants as compared with low-stress pregnancies (95% CI 1.33-6.83, P = .007).
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J Pediatr. 2018 Jun 14.
Maternal Perceived Stress during Pregnancy Increases Risk for Low Neonatal Iron at Delivery and Depletion of Storage Iron at One Year.
Rendina DN, et al.

[Dr.Vad]

Если дошколятам готовить в железной/чугунной посуде на протяжении 4 мес., то их гемоглобин остается прежним, а у тех, у кого была анемия, она ликвидируется, тогда как готовка в дюралевой посуде ассоциируется со снижением уровня гемоглобина у детей:

Children (preschoolers aged 4-5 y for 16 wk.) were cluster randomized to either eating from iron pots (Group A) or aluminum pots (Group B). Primary outcome variables were change in hemoglobin concentration and anemia prevalence.
At baseline, for group A, mean hemoglobin concentration was 122.6 ± 10.2 g/dL and 122.9 ± 9.5 g/L after intervention, p = 0.78. In group B, mean baseline hemoglobin was 123.4 ± 10.4 g/L, and 121.3 ± 8.6 g/L after intervention, p = 0.07. All ten participants, who were anemic at baseline, were no longer anemic after intervention.
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Indian J Pediatr. 2018 Jan 11.
Iron Pots for the Prevention and Treatment of Anemia in Preschoolers.

[Dr.Vad]

Риск бактериемии /сепсиса увеличен в полтора раза у людей с железодефицитом:

In age- and sex-adjusted analyses, BSI risk was increased among participants with indices of iron deficiency, serum iron ≤ 2.5th percentile (HR 1.72, 95% CI 1.34-2.21), Tsat ≤ 2.5th percentile (HR 1.48, 95% CI 1.12-1.96) or TIBC ≥ 97.5th percentile (HR 1.46, 95% CI 1.06-2.01). The associations remained similar after adjusting for comorbidities and exclusion of BSI related to cancer, rheumatic illnesses and inflammatory bowel disease. BSI mortality showed similar associations.
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Intensive Care Med. 2018 Jul 23.
Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway.
Mohus RM и соавт.